Table 3.
Distribution of hsCRP and IL6 levels in serum by study sample and dementia status.
| Nested case-control (incident) sample | Patient case-control (prevalent) sample | |||||
|---|---|---|---|---|---|---|
| Dementia | AD | Controls | Dementia | AD | Controls | |
| hsCRP (mg/L) | N=179 | N=91 | N=358 | N=93 | N=67 | N=205 |
| Geometric mean±SD | 2.0 ± 3.1 | 1.8 ± 3.0 | 2.1 ± 3.1 | 3.1 ± 3.7 | 2.5 ± 3.9 | 2.6 ± 3.4 |
| Median | 2.1 | 1.9 | 2.0 | 2.8 | 2.4 | 2.6 |
| 25th/75th percentile | 1.0/4.3 | 0.9/3.7 | 1.0/4.3 | 1.4/5.1 | 1.2/4.4 | 1.2/5.5 |
| Interquartile range | 3.3 | 2.8 | 3.3 | 3.7 | 3.2 | 4.3 |
| Bottom Tertile, N (%) | 60 (33.5) | 32 (35.2) | 121 (33.8) | 27 (29.0) | 23 (34.3) | 68 (33.2) |
| Middle Tertile, N (%) | 60 (33.5) | 32 (35.2) | 119 (33.2) | 36 (38.7) | 27 (40.3) | 69 (33.7) |
| Top Tertile, N (%) | 59 (33.3) | 27 (29.7) | 118 (33.0) | 30 (32.3) | 17 (25.4) | 68 (33.2) |
| Ptrend (tertiles) | ns | ns | ref | ns | ns | ref |
| IL6 (ng/L) | N=164 | N=82 | N=352 | N=97 | N=71 | N=198 |
| Geometric mean±SD | 2.4 ± 1.8 | 2.5 ± 1.8 | 2.3 ± 1.9 | 4.3 ± 1.9** | 4.1 ± 2.0* | 3.0 ± 1.9 |
| Median | 2.4 | 2.4 | 2.3 | 4.1** | 3.7* | 2.8 |
| 25th/75th percentile | 1.7/3.4 | 1.6/3.4 | 1.6/3.3 | 2.7/7.1 | 2.4/6.9 | 2.0/4.6 |
| Interquartile range | 1.7 | 1.8 | 1.7 | 4.4 | 4.5 | 2.6 |
| Bottom Tertile, N (%) | 47 (28.7) | 25 (30.5) | 118 (33.5) | 17 (17.5) | 16 (22.5) | 66 (33.3) |
| Middle Tertile, N (%) | 55 (33.5) | 26 (31.7) | 117 (33.2) | 28 (28.9) | 21 (29.6) | 66 (33.3) |
| Top Tertile, N (%) | 62 (37.0) | 31 (37.8) | 117 (33.2) | 52 (53.6) | 34 (47.9) | 66 (33.3) |
| Ptrend (tertiles) | ns | ns | ref | <.001 | 0.02 | ref |
*
p<0.05,
**
p<0.001 comparing cases to controls