Table IV. Functional annotation of colonosphere-enriched “Cell Death” proteins. The 20 colonosphere-enriched cell death regulators that were identified by Ingenuity were classified according to their pro-and anti-apoptotic function, based on literature.

Protein	Gene	Accession number	Fold change	Anti-apoptotic	Pre-apoptotic
Glutathione peroxidase 2 (gastrointestinal)	GPX2	IPI00298176	∞	+
Baculoviral IAP repeat-containing 6	BIRC6	IPI00299635	∞	+
Eukaryotic translation initiation factor 3, subunit H	EIF3H	IPI00647650	∞	+
C-terminal binding protein 1	CTBP1	IPI00012835	∞	+
Armadillo repeat containing 10	ARMC10	IPI00217968	∞	+
Succinate dehydrogenase complex, subunit B, iron sulfur	SDHB	IPI00294911	9.2	+	+
RNA binding motif protein 25	RBM25	IPI00004273	8.7	+	+
E1A binding protein p400	EP400	IPI00064931	8.2	+
PTK2 protein tyrosine kinase 2	PTK2	IPI00012885	4.8	+
Aldehyde dehydrogenase 1 family, member A1	ALDH1A1	IPI00218914	3.4	+
ATP-binding cassette, sub-family B (MDR), member 1	ABCB1	IPI00027481	3.8	+
BCL2-associated X protein	BAX	IPI00071059	3.0		+
Succinate dehydrogenase complex, subunit A	SDHA	IPI00305166	2.6	+
Huntingtin	HTT	IPI00002335	∞	+	+
Translocase of inner mitochondrial membrane 50	TIMM50	IPI00418497	3.1	+
Mediator of DNA-damage checkpoint 1	MDC1	IPI00470805	2.9	+	+
Minichromosome maintenance complex component 2	MCM2	IPI00184330	1.7	+
TNF receptor-associated protein 1	TRAP1	IPI00030275	1.6	+
Protein kinase, DNA-activated, catalytic polypeptide	PRKDC	IPI00296337	1.4	+
Heat shock 70kDa protein 4	HSPA4	IPI00002966	1.3	+