Fig. 5.

Role of SRC family kinases and c-MET in the survival of HNSCC cell lines. a, high EGFR-expressing cells respond more strongly to Dasatinib treatment than low expressing cells. b, siRNA-mediated protein knockdown of known Dasatinib targets in the highly Dasatinib-sensitive cell line UTSCC87 shows that differential killing observed in a can be attributed to inhibition of several proteins including EPHA2. c, high and low c-MET-expressing cell lines respond similarly to the selective c-MET inhibitor PHA665752. d, siRNA-mediated c-MET knockdown of low (gray) and high (black) c-MET-expressing cell lines shows no significant effect on cell viability.