Fig. 3.

Enriched annotation terms and pathways among the human proteins that interacted with DENV. A, Enriched terms identified by the DAVID Bioinformatics Database in the complete set of human proteins that interacted with DENV proteins in this study (68, 69). Graph shows the –log₁₀-transformed Benjamini-corrected p values for each term. Terms were grouped according to their functional similarity. Enriched features of human proteins that interacted with individual viral proteins are listed in supplemental Table S6. B, Subnetwork of human plasma proteins that interacted with DENV. Diamonds indicate DENV proteins. Ovals represent human proteins. Shading indicates human proteins annotated with the term “Complement and coagulation cascade.”