Fig. 6.

Connectivity among and between Munich Information Center for Protein Sequences complexes. A, The number of interactions between proteins among the constituent functional complexes associated with RNA synthesis (rows and columns 1–5), Chromatin remodeling (rows and columns 6–9), and Other DNA interactions (rows and columns 10–15) are color-coded from none (dark) to three or more (bright red). The number of proteins in each of the 15 complexes is given in square brackets below the graph. Abbreviations: TFIIF, Transcription factor complexes II F; TFIIIC, Transcription factor complexes III C; SWI/SNF, SWItch/Sucrose NonFermentable; TAFIIs, TATA-binding protein associated factors; SAGA, Spt/Ada/GCN5/acetyltransferase; NuA4, nucleosome acetyltransferase of H4. B, The link between the cellular locations of proteins and the different protein transport assemblies that interact with these proteins. The figure shows the connection Z-score (See Methods) associated with co-occurring protein labels of interacting proteins as a function of their locations (rows and columns 1–5) and association with different transporter complexes (rows and columns 6–16). Abbreviations: ER, Endoplasmic reticulum; TIM, the inner mitochondrial membrane protein translocase; TOM, transport across the outer membrane; GIM, prefoldin protein complex; t-SNARE, target SNAP (Soluble NSF Attachment Protein) Receptor; v-SNARE, vesicle SNAP (Soluble NSF Attachment Protein) Receptor; AP-2, Adaptor protein complex-2; AP-3, Adaptor protein complex-3; ERV25, ER Vesicle 25.