TABLE 2.

OR (95% CI) for the associations between daily intakes of total and specific lignans with breast tumor characteristics in the RPCI DBBR¹²

		Tumor status		Stage			Grade
Lignan intake, μg/d	Case status	In situ	Invasive	I	II	III/IV	1	2	3
Premenopausal women (n = 416)
Total lignans
<119	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
119–187	0.80 (0.49–1.31)	1.14 (0.50–2.62)	0.74 (0.44–1.25)	0.52 (0.26–1.02)	0.84 (0.42–1.69)	1.05 (0.37–2.99)	0.86 (0.14–5.27)	1.24 (0.53–2.87)	0.66 (0.37–1.18)
>187	0.51 (0.29–0.90)	0.71 (0.26–1.97)	0.48 (0.26–0.86)	0.51 (0.25–1.06)	0.46 (0.20–1.09)	0.43 (0.11–1.73)	0.97 (0.12–7.91)	0.60 (0.22–1.66)	0.43 (0.22–0.85)
Lariciresinol
<38.6	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
38.6–61.5	0.63 (0.38–1.05)	0.65 (0.26–1.61)	0.63 (0.37–1.07)	0.45 (0.22–0.89)	0.66 (0.32–1.35)	1.49 (0.51–4.33)	0.39 (0.05–3.00)	0.72 (0.30–1.68)	0.67 (0.37–1.21)
>61.5	0.50 (0.29–0.87)	0.84 (0.34–2.07)	0.44 (0.25–0.80)	0.46 (0.23–0.94)	0.40 (0.17–0.92)	0.51 (0.13–2.08)	4.13 (0.45–38.23)	0.38 (0.14–1.04)	0.42 (0.22–0.83)
Secoisolariciresinol
<47.5	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
47.5–74.8	0.83 (0.51–1.37)	1.36 (0.57–3.25)	0.74 (0.44–1.25)	0.65 (0.34–1.27)	0.47 (0.22–1.02)	1.61 (0.56–4.58)	0.90 (0.16–5.06)	0.97 (0.41–2.31)	0.69 (0.38–1.24)
>74.8	0.78 (0.44–1.38)	1.54 (0.56–4.23)	0.68 (0.37–1.23)	0.68 (0.32–1.44)	0.81 (0.36–1.81)	0.45 (0.10–2.07)	0.67 (0.09–5.22)	0.98 (0.37–2.60)	0.62 (0.31–1.23)
Matairesinol
<2.6	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
2.6–4.4	0.95 (0.57–1.57)	1.93 (0.81–4.60)	0.81 (0.48–1.38)	0.79 (0.40–1.53)	0.74 (0.35–1.56)	1.43 (0.49–4.24)	0.79 (0.16–3.98)	0.85 (0.34–2.12)	0.76 (0.42–1.38)
>4.4	0.64 (0.36–1.14)	0.96 (0.33–2.78)	0.60 (0.33–1.09)	0.52 (0.24–1.13)	0.75 (0.33–1.73)	0.57 (0.16–2.06)	0.07 (0.01–1.08)	1.13 (0.42–3.03)	0.46 (0.23–0.92)
Pinoresinol
<18.9	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
18.9–37.4	0.71 (0.43–1.17)	0.84 (0.37–1.93)	0.68 (0.40–1.15)	0.45 (0.23–0.91)	0.86 (0.42–1.76)	1.18 (0.41–3.40)	1.03 (0.18–5.87)	0.75 (0.32–1.77)	0.65 (0.36–1.18)
>37.4	0.47 (0.27–0.81)	0.46 (0.17–1.22)	0.47 (0.27–0.83)	0.48 (0.24–0.98)	0.42 (0.18–0.99)	0.51 (0.14–1.84)	1.24 (0.18–8.74)	0.53 (0.21–1.38)	0.48 (0.25–0.91)
Postmenopausal women (n = 878)
Total lignans
<119	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
119–187	0.77 (0.54–1.10)	0.80 (0.42–1.53)	0.77 (0.53–1.12)	0.84 (0.55–1.28)	0.79 (0.45–1.39)	0.22 (0.06–0.85)	0.86 (0.39–1.93)	0.94 (0.54–1.66)	0.72 (0.46–1.13)
>187	0.69 (0.47–1.02)	0.65 (0.32–1.32)	0.70 (0.47–1.06)	0.82 (0.52–1.30)	0.55 (0.29–1.05)	0.71 (0.23–2.16)	0.58 (0.22–1.51)	0.64 (0.34–1.22)	0.85 (0.53–1.36)
Lariciresinol
<38.6	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
38.6–61.5	0.76 (0.54–1.08)	0.72 (0.38–1.36)	0.77 (0.54–1.12)	0.70 (0.46–1.07)	1.02 (0.59–1.76)	0.62 (0.21–1.82)	0.60 (0.27–1.34)	0.83 (0.48–1.44)	0.83 (0.54–1.28)
>61.5	0.72 (0.50–1.04)	0.67 (0.34–1.32)	0.73 (0.50–1.08)	0.79 (0.52–1.21)	0.64 (0.34–1.18)	0.83 (0.29–2.39)	0.42 (0.17–1.07)	0.75 (0.41–1.36)	0.86 (0.55–1.34)
Secoisolariciresinol
<47.5	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
47.5–74.8	0.86 (0.60–1.23)	0.96 (0.49–1.87)	0.85 (0.58–1.23)	0.83 (0.54–1.26)	1.04 (0.59–1.83)	0.35 (0.11–1.19)	0.91 (0.40–2.05)	0.72 (0.41–1.26)	0.91 (0.58–1.40)
>74.8	0.91 (0.61–1.36)	1.08 (0.52–2.25)	0.88 (0.58–1.34)	0.89 (0.56–1.43)	0.86 (0.44–1.66)	1.52 (0.45–5.17)	0.81 (0.31–2.13)	0.67 (0.35–1.27)	1.05 (0.64–1.71)
Matairesinol
<2.6	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
2.6–4.4	0.70 (0.49–0.99)	0.94 (0.51–1.73)	0.65 (0.45–0.94)	0.54 (0.36–0.81)	0.98 (0.56–1.72)	0.85 (0.33–2.21)	0.73 (0.33–1.59)	0.73 (0.42–1.25)	0.61 (0.39–0.94)
>4.4	0.57 (0.38–0.84)	0.54 (0.25–1.15)	0.57 (0.38–0.87)	0.55 (0.35–0.86)	0.79 (0.41–1.49)	0.35 (0.09–1.33)	0.42 (0.16–1.09)	0.48 (0.25–0.92)	0.73 (0.45–1.17)
Pinoresinol
<18.9	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
18.9–37.4	0.88 (0.62–1.25)	1.08 (0.58–1.99)	0.84 (0.58–1.22)	0.87 (0.58–1.31)	0.83 (0.47–1.47)	0.66 (0.24–1.79)	0.87 (0.40–1.89)	0.98 (0.57–1.70)	0.79 (0.51–1.22)
>37.4	0.77 (0.53–1.11)	0.62 (0.30–1.25)	0.80 (0.55–1.17)	0.83 (0.54–1.27)	0.89 (0.50–1.60)	0.48 (0.16–1.47)	0.51 (0.20–1.29)	0.69 (0.38–1.25)	1.03 (0.66–1.60)

¹Values are OR and 95% CI for risk of each tumor characteristic compared to women without breast cancer estimated with logistic regression adjusting for education, age at menarche, BMI, age, cigarette smoking status, alcohol intake, family history of breast cancer, parity and age at first birth (combined variable), history of diabetes, and total energy intake. Models for postmenopausal women further adjusted for age at menopause. DBBR, Databank and BioRepository; RPCI, Roswell Park Cancer Institute.

²All analyses except in situ vs. invasive cancer were limited to those women with invasive cancer. In analyses for each tumor characteristic, cases were limited to women with known values for that characteristic.