FIGURE 3.

Ex vivo production of IL-10 (A), TGFβ1 (B), IL-6 (C), IL-12p40 (D), TNFα (E), and IL-1β (F) by splenic CD11c^hi DC from WT and Fat-1 mice exposed to 3 cycles DSS and cultured for 24 h with or without 10 mg/L LPS. Bars represent mean ± SEM, n = 3 (WT) or 4 (Fat-1) pooled samples from 4–5 mice. P values for effects of G, T, and G × T are shown. Means without a common letter differ, P < 0.05. DC, dendritic cell; DSS, dextran sodium sulfate; G, genotype; G × T, interaction of genotype and treatment; T, treatment; WT, wild type.