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. Author manuscript; available in PMC: 2011 Dec 14.
Published in final edited form as: Nat Genet. 2009 Dec 13;42(1):53–61. doi: 10.1038/ng.496

Figure 6.

Figure 6

Ectopic genes enter endogenous transcriptional networks. (a) Representative double-label RNA FISH for HBB transgenes (red) and endogenous Hba or Hbb genes (green) in definitive erythroid cells from transgenic lines (as indicated at top right of each panel), DAPI staining in blue. Scale bar, 2 μm. (b) Interchromosomal colocalization frequencies between HBB and Hba (blue bars) and HBB and Hbb (red bars) from six transgenic lines. Fold differences in transgene colocalization with Hbb versus Hba are shown along with the corresponding indicators of P values *P < 0.05; **P < 0.005; ***P < 0.001.