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. 2011 Dec 14;6(12):e28273. doi: 10.1371/journal.pone.0028273

Figure 2. Phenotype analysis of BPA early-life exposure toxicity in GFP transgenic fish larvae.

Figure 2

(A) Tg(Nkx2.2a-mEGFP) zebrafish larvae exposed to vehicle (control), 500 µg/L BPA and 5000 µg/L BPA. Panel on the right represent the inset region marked by white-outlined box in the corresponding left panel. White arrows indicate axon branching which are normal in control fish but marginally and severely affected in fish exposed to 500 and 5000 µg/L BPA, respectively. (B) ET(krt8-EGFP)sqet20 zebrafish larvae exposed to vehicle (control), 500 µg/L BPA and 5000 µg/L BPA. Panel on the right represent the inset region marked by white-outlined box in the corresponding left panel. White arrows indicate neuromast cells which are rosette circular-like shape in control fish but severely deformed in fish exposed to 500 and 5000 µg/L BPA. (C) Tg(Flia-EGFP)y1 zebrafish larvae exposed to vehicle (control), 500 µg/L and 5000 µg/L BPA. White arrow indicate vascularization in abdominal region which is normal in control fish but suppressed in fish exposed to 500 and (R) 5000 µg/L BPA.