Table 1. Human homolog of zebrafish genes (38) that were significantly deregulated in all three BPA exposed groups (500 µg/L, 1500 µg/L and 4500 µg/L).
| Gene Symbol [Description] | Mean Fold-Change (Log2 Ratio)a | Function | Endocrine-regulatedb |
| CSRP2BP [CSRP2 binding protein]* | 0.98 | others | |
| NCLN [nicalin]* | 0.88 | enzyme (peptidase) | |
| U1SNRNPBP [U11/U12 snRNP]* | 0.86 | others | |
| ETFA [electron-transfer-flavoprotein, alpha polypeptide] | 0.68 | transporter | |
| MRPS9 [mitochondrial ribosomal protein S9] | 0.67 | others | |
| MDM1 [Transformed 3T3 cell double minute 1]* | 0.61 | others | |
| ATP5F1 [ATP synthase, F0 complex, subunit B1]* | 0.57 | transporter | |
| CAMK2D [CaM kinase II delta]* | 0.55 | enzyme (kinase) | |
| ZNF384 [zinc finger protein 384; CIZ/Nmp4]* | 0.54 | transcription regulator | Parathyroid |
| TRAM2 [translocation associated membrane protein 2] | 0.52 | transporter | |
| METAP1 [methionyl aminopeptidase 1] | 0.45 | enzyme (peptidase) | |
| EGR2 [early growth response 2; Krox20]* | 0.44 | transcription regulator | E2 |
| SP4 [specificity protein 4]* | 0.41 | transcription regulator | E2 |
| GABPA [GA binding protein transcription factor, alpha subunit; NRF2a]* | 0.38, −0.43c | transcription regulator | Thyroid and E2 |
| AXIN1 [axin 1] | −0.22, 0.20d | signal transducer | |
| FEM1B [fem-1 homolog b] | −0.36 | others | |
| FIP1L1 [FIP1 like 1] | −0.38 | others | |
| RND3 [Rho family GTPase 3] | −0.38 | enzyme (GTPase) | E2 |
| MOSPD1 [Motile sperm domain containing 1] | −0.40 | others | |
| MID1IP1 [MID1 interacting protein 1] | −0.42 | others | |
| YIPF1 [Yip1 domain family, member 1]* | −0.43 | transporter | |
| SRPX [sushi-repeat-containing protein, X-linked] | −0.46 | others | |
| LIM2 [lens intrinsic membrane protein 2]* | −0.46 | others | |
| BLNK [B-cell linker] | −0.46 | signal transducer | E2 |
| HSD17B8 [hydroxysteroid (17-beta) dehydrogenase 8]* | −0.48 | enzyme (metabolic) | E2 and E2 metabolism |
| LRRC4 [leucine rich repeat containing 4] | −0.52 | others | Antithyroid (Propylthiouracil) |
| ACTG1 [actin, gamma 1] | −0.52 | structural protein | |
| CPA2 [carboxypeptidase A2 (pancreatic)] | −0.56 | enzyme (peptidase) | E2 |
| XRN2 [5′-3′ exoribonuclease 2] | −0.57 | enzyme (nuclease) | |
| PCID2 [PCI domain containing 2] | −0.58 | others | |
| SLC34A2 [solute carrier family 34, member 2; NAPI2] | −0.59 | transporter | E2 and Thyroid |
| SH2D5 [SH2 domain containing 5] | −0.61 | others | |
| CD74 [CD74 major histocompatibility complex] | −0.61 | transmembrane receptor | |
| NDRG1 [N-myc downstream regulated 1]* | −0.62 | enzyme (kinase) | E2 |
| PRSS33 [protease, serine, 33] | −0.69 | enzyme (peptidase) | |
| POP5 [processing of precursor 5] | −0.70 | enzyme (nuclease) | |
| SSR2 [signal sequence receptor, beta] | −0.74 | others | E2 |
| ACADM [acyl-Coenzyme A dehydrogenase; MCAD]* | −0.80 | enzyme (metabolic) | E2 |
*the zebrafish genes were subsequently validated using real-time PCR on a new batch of fish.
a
average expression fold-change above control (log2 ratio) for 500 µg/L, 1500 µg/L and 4500 µg/L BPA (microarray data).
b
refer to Table S6 for references reporting on the endocrine regulation of the genes.
c
up-regulated at 500 µg/L but down-regulated at 1500 µg/L and 4500 µg/L BPA (microarray data).
d
down-regulated at 500 µg/L but up-regulated at 1500 µg/L and 4500 µg/L BPA (microarray data).