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. 2011 Dec 14;6(12):e28344. doi: 10.1371/journal.pone.0028344

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Solid boxes represent time dependent variables, italics represent variables assumed to be time independent, dashed boxes represent variables with inhibitory or activating effects, dashed arrows represent more than one enzymatic reaction taking place. Blue boxes represent metabolites in common with the ergosterol pathway from Fig. 1. Abbreviations for the time dependent variables: 3-Keto-Sphinganine (KDHS), X₁; Sphinganine (DHS), X₂; Dihydroceramide (Dihydro-C), X₃; Sphinganine-1P (DHS-P), X₄; 4-OH-Sphinganine (PHS), X₅; Phytosphingosine-1P (PHS-P), X₆; Phytoceramide (Phyto-C), X₇; Inositol Phosphorylceramide (IPC-g), X₈; CDP-Diacylglycerol (CDP-DAG), X₉; Phosphatidylserine (PS), X₁₀; Phosphatidic Acid (PA), X₁₁; Palmitoyl-CoA (Pal-CoA), X₁₂; Serine, X₁₃; sn-1,2-Diacylglycerol (DAG), X₁₄; Phosphatidylinositol (PI), X₁₅; Inositol (I), X₁₆; Cytidine Diphosphate-Ethanolamine (CDP-Eth), X₁₇; Mannosylinositol Phosphorylceramide (MIPC-g), X₁₈; Mannosyldiinositol Phosphorylceramide (M(IP)₂C-g), X₁₉; Inositol Phosphorylceramide in Plasma Membrane (IPC-m), X₂₀; Mannosylinositol Phosphorylceramide in Plasma Membrane (MIPC-m), X₂₁; Mannosyldinositol Phosphorylceramide in Plasma Membrane (M(IP)₂C-m), X₂₂; Very Long Chain Fatty Acid (C₂₆-CoA), X₂₃; Malonyl-CoA (Mal-CoA), X₂₄; Acetyl-CoA (Ac-CoA), X₂₅; Endoplasmic reticulum ergosterol (Ergosterol), X₃₂; Plasma Associated, Detergent Insoluble ergosterol (Ergosterol-r), X ₃₇; Internal Acetate (Acetate Int.), X ₃₈.