Figure 6. Yeast ergosterol diagram based on the highest sterol related SL-E logarithmic gains (metabolites) from Table S6.

The diagram summarizes the ten time dependent metabolites of the ergosterol pathway associated with the highest sum of logarithmic gain magnitudes that are bigger than 1 (see Fig. 1 and Table S6). Solid boxes show time dependent variables and italics represent time independent variables. Consecutive arrows represent multiple enzymatic reactions, and the dashed arrow indicates a feedback signal. Blue boxes represent metabolites that also appear in the sphingolipid pathway (Fig. 2). Abbreviations for the time dependent variables: Acetyl-CoA (Ac-CoA), X₂₅; Endoplasmic reticulum ergosterol (Ergosterol), X₃₂; Steryl Lanosterol, X₃₃; Steryl Zymosterol, X₃₄; Steryl Ergosterol in Bulk Lipid Particles (Steryl Ergosterol-1), X ₃₅; Outer Leaflet Ergosterol in the Plasma Membrane (Ergosterol-o), X ₃₆; Detergent insoluble plasma associated ergosterol (Ergosterol-r), X ₃₇; Internal Acetate (Acetate Int.), X ₃₈; Inner Leaflet Ergosterol in the Plasma Membrane (Ergosterol-i), X ₃₉; Steryl Ergosterol in Plasma Membrane Associated Lipid Particles (Steryl Ergosterol-2), X ₄₀; Golgi Associated Complex Sphingolipids (CS-g), X ₈+X ₁₈+X ₁₉; Plasma Membrane Associated Complex Sphingolipids (CS-m), X ₂₀+X ₂₁+X ₂₂.