Table 1. Steady-state total mass of ergosterol sub-populations in the SL-E model under different experimental conditions, after 60 min.
ER Erg. | PM Outer Erg. | DIM Erg. | PM Inner Erg. | |
X 32 | X 36 | X 37 | X 39 | |
Wild Type (% total sterols) | 9,51 | 4.75 | 42.80 | 47.55 |
1% SPT | 1.09 | 1.20 | 0.74 | 1.13 |
1% SPT (120 min) | 1.20 | 1.28 | 0.45 | 1.23 |
1% IPC synthase | 1.05 | 1.19 | 0.72 | 1.11 |
12.5% Ceramide synthase | 1.03 | 1.04 | 0.95 | 1.03 |
Wild type condition is represented with basal values; the other experimental conditions correspond to fold changes with respect to the wild type after decreasing the specific activity of serine palmitoyl transferase (X 157), IPC synthase (X 133), and ceramide synthase (X 134) to 1% or 12.5%.