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. 2011 Dec 14;6(12):e28710. doi: 10.1371/journal.pone.0028710

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Venkatareddy et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. Increase association of Nephrin with Ship2, Filamin and Lamellipodin in protamine sulfate injury model. Glomerular lysates form mouse perfused with protamine sulfate, protamine sulfate followed by heparin sulfate and PBS (con) were immunoprecipitated with Nephrin antibody and blotted for Ship2, Filamin and Lamellipodin. B and C. There is increased Ship2 and Filamin phosphorylation following podocyte injury. There is increase in Ship2^Y1135 and Ship2^Y986/987 and Filamin^S2152 phosphorylation in glomerular lysates from PAN (puromycin aminonucleoside) and protamine sulfate treated animals. Glomerular lysates from rats injected with PBS (control) or PAN were lysed and immunoblotted as shown. Similarly, mice were injected with protamine sulfate and heparan sulfate where indicated. WB, Western blot; IP, immunoprecipitation.