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. 2011 Dec 14;6(12):e28710. doi: 10.1371/journal.pone.0028710

Figure 9. Schematic of proposed signaling.

Figure 9

Nephrin activation results in Src kinase Fyn dependent phosphorylation on tyrosine residues as shown. Phosphorylation on Nephrin Y5,7,10 results in Nck dependent Pak1 recruitment. This further result in recruitment of the Filamin-Ship2 complex at the leading edge and is dependent on phosphorylation of Filamin S2152. Ship2 is enriched at the leading edge and dephosphorylates PI (3,4,5)P3 to PI (3,4)P2 and recruitment of Lamellipodin. It has been demonstrated previously by us and others that Nephrin recruits p85 subunit of PI3 kinase [10], [35].