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. 2011 Dec 14;6(12):e28844. doi: 10.1371/journal.pone.0028844

Table 2. Results of meta-analysis of blood vessel invasion and prognosis in NSCLC.

Groups Estimate of relative hazard Homogeneity test
HR 95% CI p Q (df) p
All studies
Unadjusted OS (31 studies, n = 8,528) 2.22 1.93–2.56 <0.0001 79.63 (33) <0.001
Adjusted OS (28 studies, n = 9,873) 1.90 1.65–2.19 <0.0001 84.40 (28) <0.001
Unadjusted RFS (11 studies, n = 4,498 ) 3.28 2.14–5.05 <0.0001 90.00 (10) <0.001
Adjusted RFS (7 studies, n = 3,088) 3.98 2.24–7.06 <0.0001 34.44 (6) <0.001
Stage I studies
Unadjusted OS (14 studies, n = 2,908 ) 2.94 2.28–3.80 <0.0001 22.83 (13) 0.044
Adjusted OS (13 studies, n = 3,974) 2.15 1.68–2.75 <0.0001 26.70 (12) 0.009
Unadjusted RFS (5 studies, n = 647) 5.89 3.98–8.71 <0.0001 3.76 (4) 0.440
Adjusted RFS (4 studies, n = 576) 6.93 4.23–11.37 <0.0001 3.61 (3) 0.306

NSCLC = non-small-cell lung cancer; HR = hazard ratio; CI = confidence interval; OS = overall survival; RFS = relapse-free survival.