Table 1. Representative HLA typing of donors used for experiments demonstrating HLA class I antigen specificity shown in Figure 3.
Cell type | HLA-A | HLA-B | HLA-DR | |||
A (CD8+CD28− cells or A-T4 | 11 | - | 18 | 35 | 1 | 7 |
B-APC | 1 | 2 | 8 | 44 | 4 | 15(2) |
C-APC | 1 | 2 | 8 | 44 | 3 | 12(5) |
I-APC | 24 | 26 | 7 | 61 | 9 | 10 |
The HLA typing of donors for CD8+ T cells for generation of CD8+CD28− suppressor cells, the priming B-APC cells, the partially matched C-APC cells (which shared identical HLA-A, -B, but not HLA-DR, with B-APC), or the fully mismatched I-APC cells (HLA-A, B and DR fully mismatched with B-APC) are shown. Two additional sets of donors A, B, C, and I were used for repeating this experiment for a total of three independent times.