Table 1. NMR Structure Determination Statistics.

	Alpha45 in H2O	Alpha45 in 1% SDS
A. Restraint Statistics
Intra-residue NOEs	82	163
Sequential NOEs (|i -j| = 1)	42	147
Medium range NOEs (2≤|i -j|≤4)	58	88
Long range NOEs (|i -j|>4)	0	22
Total NOE restraints	182	416
Hydrogen bonds restraints	0	36
Dihedral angle restraints	58	62
Total Restraints	182	515
B. Ensemble Statistics Analysis
RMSD values (Å)
Backbone heavy atoms (helix Ia)	0.26±0.09b	0.17±0.08
All heavy atoms (helix I)	1.26±0.17	0.67±0.13
Backbone heavy atoms (helix IIc)	0.37±0.11d	0.21±0.07
All heavy atoms (helix II)	1.28±0.21	0.95±0.12
Backbone heavy atoms of helices I and II	n/a	0.38±0.10
All heavy atoms	n/a	0.93± 0.12
Statistics from Ramachandran plot e
Residues in most favored regions (%)	88	83
Residues in additional allowed regions (%)	11	17
Residues in generously allowed regions (%)	0.7	0
Residues in disallowed regions (%)	0.3	0

^a Helix I in SDS includes residues 243 to 254.

^b Helix I in H₂O includes 247–253.

^c Helix II in SDS includes residues 264 to 277.

^d Helix II in H₂O includes residues 266 to 276.

^e Value averaged for 14 structures.