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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2011 Nov;70(11):1006–1019. doi: 10.1097/NEN.0b013e31823557fb

Figure 3.

Figure 3

Somatodendritic distribution of 4R-tau in the cingulate gyrus (CG) of E391 transgenic mice. (A–F) Coronal paraffin sections were stained with the 4R-tau specific antibody RD4, which recognizes both mouse and human 4R-tau (A–C) or with the human specific tau antibody T14 (D–F). Non-transgenic (NTG) mice exhibit a normal axonal distribution of 4R-tau in the CG (A). Somatodendritic distribution of 4R-tau in the CG is detectable with the 4R-tau specific (B) and human tau specific (E) antibodies in E391-3608 mice (lower expressers). Only the human specific tau antibody demonstrates somatodendritic localization in the CG in E391-3610 mice (higher expressers) (C, F). *Granular dot-like neuritic processes in CG and supracallosal regions. Inset in (C) is a higher power of boxed region showing granular dot-like neuritic processes. Scale bars: A–F, 100 μm; inset in C, 25 μm.