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. 2011 Dec 15;22(24):4776–4786. doi: 10.1091/mbc.E11-09-0778

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© 2011 Mese et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 2: — Cx26-G45E expression induces hemichannel currents. Untransfected N2A cells (A) and N2A cells transfected with wild-type Cx26 (B) had similar membrane currents when stepped to membrane potentials between −90 and +90 mV. N2A cells expressing Cx26-G45E induced much larger whole-cell membrane currents at both hyperpolarizing and depolarizing potentials (C). A plot of current density vs. voltage (D) showed that Cx26-G45E currents were significantly larger than those recorded in either untransfected or wild-type Cx26 expressing cells at all tested voltages (p < 0.01, ANOVA). In addition to whole-cell membrane currents, single-channel activity was observed in Cx26-G45E–transfected cells with a unitary conductance value of ∼320 pS (E), consistent with the size expected for a Cx26 hemichannel.