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. 2011 Dec 15;22(24):4776–4786. doi: 10.1091/mbc.E11-09-0778

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© 2011 Mese et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 6: — Histological analysis of Cx26-G45E transgenic skin. Adult head skin samples from control animals (A) displayed normal epidermal and dermal morphology after 4 wk of doxycycline application. In contrast, K14-rtTA plus TRE-G45E double-transgenic mice (B) induced for 4 wk demonstrated massive skin hyperplasia with greatly increased thickening of the epidermis (acanthosis), papillomatosis (undulation of the epidermis into the dermis), and a thickened, compact stratum corneum (hyperkeratosis). Animals maintained on doxycycline for 10 wk had pronounced hyperkeratosis with frequent keratotic plugging and sebaceous gland atrophy (C). A and B were photographed with a 20× objective (scale bar, 50 μm), and C was photographed with a 4× objective (scale bar, 100 μm).