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Matched CK-positive and negative cells in circulation and primary tumor. (a) CK-negative ovarian cancer cells identified in circulation (top) at the time of surgical resection have similar aneuploidy as regions in the tumor (bottom). Represented are cells with trisomy of chromosome 8. (b) CK staining of ovarian carcinoma samples reveals CK-negative cells with aneuploidy (arrows) similar to those detected in circulation. Approximately 20% of the tumor had such CK-negative cells.
