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. 2011 Dec 12;61(1):124–136. doi: 10.2337/db11-0998

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© 2012 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 8. — Summarizing the role of BAMBI in adipogenesis. A: Schematic showing BAMBI’s position in the adipogenic program. BAMBI is downregulated in response to FGF-1, in a PI3K-dependent manner, or induction of adipogenesis. Decreased BAMBI promotes increased PPARγ, leading to increased adipogenesis. B: Schematic summarizing BAMBI’s modulatory effects on autocrine/paracrine adipogenic factors. BAMBI facilitates (arrows) the antiadipogenic actions of TGF-β1 signaling and Wnt3a signaling (blocks) and the proadipogenic actions of BMP-4 signaling on PPARγ, leading to decreased or increased adipogenesis, respectively.