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. 2011 Dec 12;61(1):49–60. doi: 10.2337/db11-0870

FIG. 3.

FIG. 3.

Stimulation of glycogen synthesis by methyl-5HT is not additive with the stimulation by a GPI. Time course of GPa depletion (% time zero) and activation of glycogen synthase (% CP-91149 at 60 min) by 100 μmol/L methyl-5HT (M5HT) (A) or 10 μmol/L CP-91149 (GPI) (B); n = 3. C: Glycogen synthesis (nmol/3 h/mg), combined effects of 100 μmol/L M5HT (black bars) with a glucokinase activator (GKA; 200 μmol/L sorbitol), a glucose-6-phosphatase inhibitor (G6PI; 2 μmol/L S4048), and a GPI (40 μmol/L CP-91149); n = 3. *P < 0.05 effect of M5HT. Combined effects of the GPI (25 μmol/L CP-91149; black bars) with sorbitol (200 μmol/L), S4048 (2 μmol/L), and methyl-5HT (100 μmol/L) on glycogen synthesis (nmol/3 h/mg) (D), GPa activity (E), and glycogen synthase (G. Synthase) activity (F); n = 3. *P < 0.05 vs. control (Con); #P < 0.05 GPI and other additions vs. GPI alone.