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. 2011 Dec 12;61(1):166–174. doi: 10.2337/db11-0790

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© 2012 by the American Diabetes Association.

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FIG. 2. — Expression of Idd5 genes by nonlymphocytes and Idd3 genes by lymphocytes is required for restoration of CD8⁺ T-cell tolerance. A: NOD-SCID, Idd5-SCID, and Idd3/5-SCID mice were reconstituted with spleen and lymph node cells depleted of DCs isolated from 3- to 4-week-old NOD or Idd3/5 donor mice. After 10 weeks, the mice were infected with Vac-K^dIGRP, and 7 days later the spleens were analyzed for CD8⁺ IGRP-tetramer⁺ cells. Pooled results from four experiments are shown. Horizontal lines depict median value. Pairs of strains were compared with the Mann-Whitney U test. *P < 0.05; **P < 0.01. B: Idd5-SCID (■) and Idd3/5-SCID (●) mice were reconstituted with spleen and lymph node cells depleted of DCs isolated from 3- to 4-week-old NOD, Idd3, Idd5, or Idd3/5 donor mice. After 10 weeks, the mice were infected with Vac-K^dIGRP, and 7 days later the spleens were analyzed for CD8⁺ IGRP-tetramer⁺ cells. Pooled results from four experiments are shown. Horizontal lines depict median value. Pairs of strains were compared with the Mann-Whitney U test. *P < 0.05; ***P < 0.001.