FIG. 6.

Requirements for expression of protective Idd3 and Idd5 subregions for protection from insulitis development. NOD-SCID, Idd5-SCID, and Idd3/5-SCID mice were reconstituted with spleen and lymph node cells depleted of DCs isolated from 3- to 4-week-old NOD, Idd3, or Idd3/5 donor mice. After 10 weeks, pancreata were harvested and hematoxylin-eosin–stained sections were assessed for insulitis. Data are pooled from four experiments. Horizontal lines depict median value. Pairs of strains were compared with the Mann-Whitney U test. *P < 0.05; **P < 0.01.