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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Curr Opin Virol. 2011 Dec 1;1(6):497–512. doi: 10.1016/j.coviro.2011.10.017

Table 1. NK Cells in Viral Infection: Evidence for Activating Receptors and Ligands.

Receptor Class Species Virus Family Virus Receptor Involvement Ligand References
Single Molecule Associated with Activating Adaptor
graphic file with name nihms339125t1.jpg
Highly Polygeneic Recognition Molecule		 Mouse Herpesviridae MCMV Ly49H m157 [21-24]
Ly49P H-2Dk (+ m04) [29]
Ly49L H-2k (+ m04) [32]
Ly49P1 [32]
Human Retroviridae HIV KIR3DS1 HLA-B (Bw4-80I) [47-50]
Herpesviridae EBV KIR2DS1 HLA-C [55]
graphic file with name nihms339125t2.jpg
Genetically-Conserved Recognition Molecule		 Mouse Orthomyxoviridae Influenza NKp46 Hemagglutinin (HA) [26]
Human Orthomyxoviridae Influenza NKp46 HA [52]
NKp30 HA [51]
Flaviviridae HCV NKp30, NKp46 ? [46,92]
Herpesviridae HSV NKp30, NKp44, NKp46 ICP10? [54]
Herpesviridae KSV NKp80 activation-induced C-type lectin [57]
Poxviridae vaccinia NKp30, NKp44, NKp46 ? [56]
Filovirus/Rhabdoviridae Ebola/Marburg NKp30 ? [53]
Molecule Associated with CD94 and Activating Adaptor
graphic file with name nihms339125t3.jpg
Genetically-Conserved Recognition Molecule		 Mouse Poxviridae Ectromelia CD94/NKG2E Qa-1b (+ ?) [33]
Human Herpesviridae HCMV CD94/NKG2C HLA-E (+?) [43]
Bunyavirdea Puumala hantavirus CD94/NKG2C HLA-E (+?) [42]
Hepadaviridae HBV CD94/NKG2C ? [45]
Flaviviridae HCV CD94/NKG2C ? [45,46]
Homodimer Associated with Activating Adaptor
graphic file with name nihms339125t4.jpg
Genetically-Conserved Recognition Molecul		 Mouse Herpesviridae MCMV NKG2D Stress Molecules (Raeα-ε, H60a-c, MULT1) [35]
Human Herpesviridae HCMV NKG2D Stress Molecules (MICA-C, ULBP1-6) [35]
Herpesviridae KSV NKG2D Stress Molecules (MICA-C, ULBP1-6) [57]