Table 2.

Hazard ratios (95% confidence intervals) for atrial fibrillation by fasting serum glucose and HbA1c levels in individuals without type 2 diabetes (defined by no history of medication use or no self-report of diabetes) (n = 12 066), ARIC, 1990–2007

	Fasting Serum Glucose (mg/dl)			P-value for trend	P-values for interactions
	<100	100–125	≥126		Gender	Race
No. AF cases	405	626	104
Person-years	73322	92274	11544
HR (95% CI) Model 1	1(REF)	1.07 (0.94–1.21)	1.48 (1.19–1.84)	0.005	0.64	0.24
HR (95% CI) Model 2	1 (REF)	0.92 (0.81–1.05)	1.02 (0.82–1.28)	0.63	0.50	0.31
HR (95% CI) excl. prev..CHD*	1 (REF)	0.90 (0.70–1.03)	0.92 (0.71–1.17)	0.20	0.82	0.21
		HbA1c (%)
	< 5.7	5.7 – 6.4	≥ 6.5
No AF cases	788	280	67
Person-years	136022	33695	7422
HR (95% CI) Model 1	1 (REF)	1.39 (1.21–1.60)	1.67 (1.30–2.15)	<0.0001	0.21	0.25
HR (95% CI) Model 2	1 (REF)	1.13 (0.98–1.30)	1.19 (0.92–1.54)	0.06	0.07	0.58
HR (95% CI) excl. prev..CHD*	1REF)	1.09 (0.94–1.27)	1.02 (0.76–1.36)	0.45	0.17	0.73

HR: Hazard ratio (95% confidence intervals); Model 1: Adjusted for age, race and sex; Model 2: Adjusted for model 1 + center, education, income, smoking status, prevalent CHD, systolic blood pressure, hypertensive medications and body mass index;

^*HR (95% CI) excluding prev. CHD: Adjusted hazard ratio (Model 2) and 95% confidence intervals after excluding those with prevalent CHD.