Table 3.

Hazard ratios (95% confidence intervals) for atrial fibrillation by fasting serum glucose and HbA1c levels in individuals with type 2 diabetes (defined by history of medication use or self-report of diabetes) (n = 959), ARIC, 1990–2007

	Fasting Serum Glucose (mg/dl)			P-value for trend	P-values for interactions
	<100	100–125	≥126		Gender	Race
No. AF cases	2	18	156
Person-years	542	1675	9683
HR (95% CI) Model 1	1(REF)	2.53 (0.58–11.0)	4.10 (1.01–16.7)	0.005	0.79	0.79
HR (95% CI) Model 2	1(REF)	1.99 (0.46–8.67)	2.89 (0.71–11.8)	0.04	0.78	0.80
HR (95% CI) excl. prev. CHD*	1 (REF)	2.07 (0.47–9.05)	2.63 (0.64–10.7)	0.11	0.89	0.54
		HbA1c (%)
	< 5.7	5.7 – 6.4	≥ 6.5
No AF cases	8	16	152
Person-years	1135	1714	9049
HR (95% CI) Model 1	1 (REF)	1.30 (0.56–3.05)	2.77 (1.36–5.65)	0.0002	0.76	0.79
HR (95% CI) Model 2	1(REF)	1.18 (0.50–2.77)	2.11 (1.02–4.37)	0.007	0.66	0.52
HR (95% CI) excl. prev. CHD*	1 (REF)	1.22 (0.49–3.05)	2.21 (1.01–4.83)	0.009	0.84	0.79
HR(95%CI) + adj FSG**	1 (REF)	1.12 (0.48–2.64)	1.69 (0.78–3.66)	0.09	0.73	0.56

HR: Hazard ratio (95% confidence intervals); Model 1: Adjusted for age, race and sex;Model 2: Adjusted for model 1 + center, education, income, smoking status, prevalent CHD, systolic blood pressure, hypertensive medications and body mass index;

^*HR (95% CI) excluding prev. CHD: Adjusted hazard ratio (Model 2) and 95% confidence intervals after excluding those with prevalent CHD;

^**Hazard ratio (95% confidence intervals) from Model 2 + adjustment for fasting serum glucose among all persons with type 2 diabetes