Table 2.
Cancer incidence rates, and rate ratios by HIV infection status
| HIV+ | HIV− | Demographic-adjustedb | Fully-adjustedb | |||||
|---|---|---|---|---|---|---|---|---|
| n | ratea | n | ratea | RR (95% CI) | P | RR (95% CI) | P | |
| Infection-related | ||||||||
| Kaposi sarcoma | 525 | 604 | 34 | 3 | 197.1 (139.2, 279.0) | <0.001 | 196.0 (138.1, 278.0) | <0.001 |
| Non-Hodgkin lymphoma | 241 | 269 | 193 | 17 | 15.9 (13.2, 19.3) | <0.001 | 15.4 (12.7, 18.7) | <0.001 |
| Anal | 86 | 96 | 18 | 2 | 60.9 (36.6, 101.4) | <0.001 | 55.7 (33.2, 93.4) | <0.001 |
| Hodgkin lymphoma | 52 | 58 | 32 | 3 | 19.8 (12.7, 31.0) | <0.001 | 18.7 (11.8, 29.5) | <0.001 |
| Oral cavity/pharynx | 26 | 29 | 183 | 16 | 1.9 (1.3, 2.9) | 0.002 | 1.4 (0.9, 2.1) | 0.14 |
| Liver | 24 | 27 | 110 | 10 | 2.6 (1.7, 4.0) | <0.001 | 1.8 (1.1, 2.8) | 0.012 |
| Infection-unrelated | ||||||||
| Prostate | 91 | 112 | 1,398 | 138 | 0.8 (0.6, 0.9) | 0.012 | 0.8 (0.6, 0.9) | 0.012 |
| Lung | 56 | 62 | 380 | 34 | 1.8 (1.4, 2.4) | <0.001 | 1.2 (0.9, 1.6) | 0.15 |
| Colorectal | 35 | 39 | 459 | 41 | 0.9 (0.6, 1.3) | 0.55 | 0.9 (0.6, 1.2) | 0.34 |
| Melanoma | 34 | 38 | 266 | 24 | 1.8 (1.3, 2.6) | 0.001 | 1.8 (1.3, 2.6) | 0.001 |
RR, rate ratio
Crude incidence rate per 100,000 person-years
RR comparing cancer incidence in HIV-infected individuals with HIV-uninfected individuals (reference group) from Poisson regression models. Demographic-adjusted model included terms for HIV status, age, sex, race/ethnicity, calendar period, and KP region. Fully-adjusted model also included terms for smoking, overweight, and alcohol/drug abuse.