Table 4.
Rate ratios (95% CI)a for cancer by recent HIV RNA among HIV-infected compared with HIV-uninfected subjects
| Recent HIV RNA copies/mL | ||||
|---|---|---|---|---|
| ≥10,000 | 501–9,999 | ≤500 | p-trendb | |
| Infection-related | ||||
| Kaposi sarcoma | 538.1 (376.4, 769.2) | 103.0 (66.0, 160.7) | 78.6 (53.5, 115.3) | <0.001 |
| Non-Hodgkin lymphoma | 48.3 (38.5, 60.7) | 14.0 (9.6, 20.4) | 6.1 (4.5, 8.1) | <0.001 |
| Anal | 51.8 (25.9, 103.3) | 48.1 (22.9, 101.1) | 58.7 (34.3, 100.5) | 0.79 |
| Hodgkin lymphoma | 24.7 (13.0, 46.7) | 11.5 (4.4, 29.8) | 18.4 (11.1, 30.4) | 0.30 |
| Oral cavity/pharynx | 0.3 (0.0, 2.0) | 2.8 (1.4, 5.8) | 1.4 (0.8, 2.2) | 0.017 |
| Liver | 1.7 (0.6, 4.5) | 0.6 (0.1, 4.1) | 2.1 (1.3, 3.4) | 0.30 |
| Infection-unrelated | ||||
| Prostate | 0.5 (0.3, 0.9) | 0.5 (0.2, 1.0) | 0.9 (0.7, 1.1) | 0.077 |
| Lung | 1.8 (1.1, 3.1) | 1.2 (0.6, 2.5) | 1.1 (0.8, 1.6) | 0.32 |
| Colorectal | 0.5 (0.2, 1.4) | 0.5 (0.2, 1.6) | 1.0 (0.7, 1.5) | 0.27 |
| Melanoma | 2.6 (1.3, 5.1) | 2.2 (1.0, 5.0) | 1.5 (1.0, 2.4) | 0.39 |
a
RRs from Poisson regression models with terms for HIV status/HIV RNA (HIV-uninfected reference group), age, sex, race/ethnicity, calendar period, KP region, smoking, overweight, and alcohol/drug abuse.
b
P-value tests trend in RRs over HIV RNA strata by the likelihood ratio test.