Table 5.
Rate ratios (95% CI)a for cancer by recent CD4 and HIV RNA among HIV-infected subjects
| Recent CD4 cells/µL | Recent HIV RNA copies/mL | |||
|---|---|---|---|---|
| ≤200 | 201–499 | ≥10,000 | 501–9,999 | |
| Infection-related | ||||
| Kaposi sarcoma | 7.5 (5.6, 10.2) | 1.9 (1.4, 2.5) | 3.8 (3.0, 4.8) | 1.2 (0.8, 1.7) |
| Non-Hodgkin lymphoma | 6.8 (4.2, 10.9) | 2.9 (1.8, 4.6) | 4.4 (3.2, 6.2) | 1.9 (1.2, 2.9 |
| Anal | 3.1 (1.6, 6.1) | 2.0 (1.2, 3.4) | 0.7 (0.4, 1.3) | 0.7 (0.4, 1.4) |
| Hodgkin lymphoma | 3.7 (1.8, 7.8) | 0.9 (0.4, 1.8) | 0.9 (0.4, 1.8) | 0.6 (0.2, 1.6) |
| Oral cavity/pharynx | 5.9 (1.8, 19.4) | 2.6 (0.9, 7.4) | 0.2 (0.0, 1.3) | 1.9 (0.8, 4.6) |
| Liver | 4.3 (1.2, 15.0) | 2.5 (0.9, 7.1) | 0.4 (0.1, 1.5) | 0.2 (0.0, 1.5) |
| Infection-unrelated | ||||
| Prostate | 0.7 (0.3, 1.6) | 1.1 (0.7, 1.7) | 0.5 (0.2, 1.1) | 0.5 (0.2, 1.1) |
| Lung | 2.0 (0.9, 4.1) | 0.9 (0.5, 1.6) | 0.9 (0.4, 1.9) | 0.9 (0.4, 2.1) |
| Colorectal | 4.8 (1.9, 12.3) | 1.7 (0.7, 3.9) | 0.5 (0.1, 1.4) | 0.6 (0.2, 1.9) |
| Melanoma | 1.8 (0.6, 6.0) | 2.3 (1.0, 5.3) | 1.9 (0.8, 4.6) | 1.5 (0.6, 3.8) |
a
RRs from Poisson regression models with terms for recent CD4 (reference: ≥500 cells/µl), recent HIV RNA (reference: ≤500 copies/ml), age, sex, race/ethnicity, calendar period, KP region, smoking, overweight, alcohol/drug abuse, prior antiretroviral therapy use, HIV risk, and years known HIV-infected.