Skip to main content
. Author manuscript; available in PMC: 2012 Dec 9.
Published in final edited form as: Circ Res. 2011 Oct 13;109(12):1396–1400. doi: 10.1161/CIRCRESAHA.111.255687

Figure 1.

Figure 1

Ruboxistaurin attenuates heart failure in pigs post MI. A, Millar catheter-based analysis of heart rate and B, contractility in vehicle or ruboxistaurin treated (10 mg/kg/day) pigs subjected to MI injury at the indicated times after injury (days or months). #P<0.05 versus 0 time point. *P<0.05 versus vehicle treated pigs at 3 months. C, left ventricular ejection fraction measured by ventriculography in vehicle or ruboxistaurin treated pigs after MI for the indicated periods of time (days or months). *P<0.05 versus vehicle at 3 months. D, Cardiac output measured with a Swan Ganz catheter in vehicle or ruboxistaurin treated pigs after MI for the indicated periods of time. *P<0.05 versus vehicle at 3 months. E, Quantitation of scar size after TTC staining to show area of injury between the 2 groups. N.S.=not significantly different. F, Pig heart slices after MI injury stained with TTC (white area is not stained by TTC and represents the area of infraction).