Table 1.
Demographic Information and Structural Volumes for Incident Cases and Non-diagnosed Participants (Based on Clinician Judgment)
| Incident | Non-diagnosed | Statistic* (p-value) |
|
|---|---|---|---|
| N | 85 | 85 | |
| Gender | 61 F 24 M |
61 F 24 M |
|
| Mean CAG repeat length (s.d.) | 43.1 (2.4) | 43.1 (2.3) | 1.0 (p = .32) |
| Mean Age at MRI (s.d.) | 44.9 (9.2) | 44.9 (9.1) | 0.98 (p = .33) |
| Years between MRI visit and “verification” visit** | 1.75 (0.77) | 2.46 (1.40) | |
| Mean UHDRS Motor Score at MRI Visit (s.d.) | 11.4 (6.6) | 4.9 (5.5) | 7.00 (p < .0001) |
| Caudate Volume | |||
| Raw (cc) ± s.d. | 4.61 (1.38) | 5.17(1.28) | |
| Corrected*** ± s.d. | .35 (.10) | .40 (.10) | 5.39 (p < .0001) |
| Putamen Volume | |||
| Raw (cc) ± s.d. | 6.01 (1.24) | 5.17(1.28) | |
| Corrected*** ± s.d. | .46 (.08) | .40 (.10) | 3.55 (p = .0006) |
| Total Striatal Volume | |||
| Raw (cc) ± s.d. | 10.63 (2.47) | 11.95 (2.58) | |
| Corrected*** ± s.d. | .81 (.17) | .92 (.20) | 5.01 (p < .0001) |
| White Matter Volume | |||
| Raw (cc) ± s.d. | 342.39 (61.29) | 357.86 (63.48) | |
| Corrected*** ± s.d | 26.06 (3.31) | 27.42 (3.57) | 2.89 (p = .0049) |
*
matched sample t-tests, based on ICV-corrected volumes (region divided by ICV) for structural measures.
**
the verification visit, which occurred 1 to 4 years after the MRI scan, is when a diagnosis of HD was made for the incident cases and the most recent visit at which the non-diagnosed participants were verified to still be free of diagnosable signs and symptoms
***
Corrected volumes = (structure volume/intracranial volume) * 100