Table 2.
Demographic Information and Structural Volumes for Participants Categorized by UHDRS Motor Score
| UHDRS Motor Score 11 and over |
UHDRS Motor Score 10 and under |
Statistic* (p-value) |
|
|---|---|---|---|
| N | 72 | 72 | |
| Gender | 49 F 23 M |
49 F 23 M |
|
| Mean CAG repeat length (s.d.) | 43.1 (2.4) | 43.0 (2.2) | .70 (p = .48) |
| Mean Age at MRI (s.d.) | 44.4 (8.7) | 44.4 (8.6) | .77 (p = .44) |
| Years between MRI visit and “verification” visit** | 1.7 (.73) | 2.5 (1.4) | |
| Mean UHDRS Motor Score at MRI Visit (s.d.) | 11.8 (6.4) | 3.6 (3.5) | 9.49 (p < .0001) |
| Caudate Volume | |||
| Raw (cc) ± s.d. | 4.7 (1.4) | 5.3 (1.3) | |
| Corrected*** ± s.d. | .35 (.10) | .41 (.10) | 3.71 (p = .0004) |
| Putamen Volume | |||
| Raw (cc) ± s.d. | 6.1 (1.3) | 7.0 (1.4) | |
| Corrected*** ± s.d. | .46 (.09) | .54 (.11) | 6.25 (p < .0001) |
| Total Striatal Volume | |||
| Raw (cc) ± s.d. | 10.8 (2.6) | 12.3 (2.5) | |
| Corrected*** ± s.d. | .81 (.17) | .94 (.19) | 5.59 (p < .0001) |
| White Matter Volume | |||
| Raw (cc) ± s.d. | 348.3 (62.4) | 364.3 (63.2) | |
| Corrected*** ± s.d | 26.10 (3.2) | 27.87 (3.3) | 3.48 (p = .0009) |
*
matched sample t-tests, based on ICV-corrected volumes (region divided by ICV) for structural measures.
**
the verification visit, which occurred 1 to 4 years after the MRI scan, is when a diagnosis of HD was made for the cases with higher UHDRS Motor Scores and the most recent visit at which those with lower UHDRS Motor Scores were verified to still be free of diagnosable signs and symptoms
***
Corrected volumes = (structure volume/intracranial volume) * 100