Table 1.
Genotype frequencies of the TERT polymorphisms among SCCHN cases and control subjects and their associations with SCCHN risk
| Genotype | Cases n = 888 (%) |
Controls n = 885 (%) |
Adjusted OR(95%CI)a |
|---|---|---|---|
| rs2735940 G>A | |||
| GG | 224 (25.2) | 221 (25.0) | 1.00 |
| GA | 440 (49.6) | 436 (49.3) | 0.99 (0.78–1.26) |
| AA | 224 (25.2) | 228 (25.7) | 1.03 (0.79–1.36) |
| rs2736098 C>T | |||
| CC | 481 (54.2) | 468 (52.9) | 1.00 |
| CT | 351 (39.5) | 356 (40.2) | 0.97 (0.79–1.19) |
| TT | 56 (6.3) | 61 (6.9) | 0.86 (0.58–1.29) |
| rs2736109 G>A | |||
| GG | 319 (35.9) | 313 (35.4) | 1.00 |
| GA | 427 (48.1) | 419 (47.3) | 1.00 (0.81–1.24) |
| AA | 142 (16.0) | 153 (17.3) | 0.92 (0.69–1.22) |
| rs2853669 T>C | |||
| TT | 428 (48.2) | 425 (48.0) | 1.00 |
| TC | 381 (42.9) | 375 (42.4) | 1.02 (0.84–1.26) |
| CC | 79 (8.9) | 85 (9.6) | 0.91 (0.64–1.29) |
| rs2853677 A>G | |||
| AA | 294 (33.1) | 311 (35.1) | 1.00 |
| AG | 448 (50.5) | 416 (47.0) | 1.09 (0.88–1.36) |
| GG | 146 (16.4) | 158 (17.9) | 1.00 (0.75–1.33) |
| rs2853690 G/A | |||
| GG | 596 (67.1) | 618 (69.8) | 1.00 |
| GA | 265 (29.8) | 228 (25.8) | 1.17 (0.94–1.45) |
| AA | 27 (3.0) | 39 (4.4) | 0.69 (0.41–1.16) |
a
Adjusted by age, sex, smoking and drinking status.