Figure 7. LAP+ T cells suppress asthmatic lung inflammation in sensitized mice.
FACS sorted LAP+Foxp3− or Foxp3+LAP− OT-II T cells, generated as described in Fig. 3, were transferred into BL/6 mice that had been sensitized with OVA and Alum for 7 days. The recipients were then challenged with OVA aerosol to induce lung inflammation starting one day later. (a) Protocol timeline. (b) Eosinophils in BAL. (c) Cytokines in BAL by ELISA. (d) Representative H&E staining of lung sections. Data are means ± SEM from 3 mice per group. Data are representative of 3 independent experiments. *P < 0.05.