Table 1. H929-60 cells are not resistant to standard myeloma therapies.
H929 and H929-60 cells were treated with increasing concentrations of melphalan or bortezomib for 24 hours. After 24 hours, cells were stained with annexin V FITC/PI for 45 minutes and acquired on FACScan. IC50 values were determined by linear regressions. Shown is the mean and standard deviations of three independent experiments.
| Compound | H929 IC50 (n=3) | H929-60 IC50 (n=3) |
|---|---|---|
| melphalan | 11.3 +/- 2.5 μM | 13.1 +/- 3.7 μM |
| mitoxantrone | 1.42 +/- .4 μM | 1.05 +/- .7 μM |
| bortezomib | 11.3 +/- 5.1 nM | 12.2 +/- 3.9 nM |