Table 2.

Polymorphisms significantly associated with tacrolimus log-transformed, normalized concentration-dose ratio (adjusted analysis). All SNPs located on chromosome 7.

SNP	Gene	Associated Allele	Reference Allele	Coefficienta	P value	Allelic Frequency in Whites	Allelic Frequency in Blacks
rs776746	CYP3A5	G	A	0.54	7.15 × 10−29	0.92	0.30
rs4646437	CYP3A4	C	T	0.35	1.05 × 10−14	0.88	0.29
rs2257401	CYP3A7	C	G	0.37	1.08 × 10−14	0.91	0.48
rs2242480	CYP3A4	C	T	0.34	5.22 × 10−14	0.89	0.26
rs12333983	CYP3A4	T	A	0.32	7.35 × 10−14	0.88	0.32
rs2687105	CYP3A4	A	T	0.36	1.83 × 10−09	0.96	0.33
rs6956344	CYP3A4	C	T	0.29	3.34 × 10−09	0.91	0.67
rs2740574	CYP3A4	A	G	0.34	6.44 × 10−09	0.96	0.34
rs1851426	CYP3A4	C	T	0.33	9.35 × 10−08	0.96	0.27
rs2687116	CYP3A4	T	G	0.30	1.61 × 10−07	0.96	0.39

^aAdjusted for age, sex, weight, hemoglobin, albumin, time since transplant, and first 10 principal components from EIGENSTRAT.