Table 3.
Results for fixed effects in the mixed-effects model for CYP3A5*3 in the longitudinal data analysis for log-transformed tacrolimus C/D ratio.
| Covariate | Coefficienta (S.E.) | P value |
|---|---|---|
| CYP3A5*3 | 0.54 (0.044) | 7.15 × 10−29 |
|
| ||
| Albuminb (x) | −0.17 (0.04) | 2.07 × 10−5 |
| (x') | 0.12 (0.04) | 0.005 |
|
| ||
| Age | 0.007 (0.002) | 1.80 × 10−5 |
|
| ||
| Weightb (x) | −0.007 (0.002) | 3.24 × 10−4 |
| (x') | 0.006 (0.002) | 0.004 |
|
| ||
| Hemoglobin | 0.015 (0.006) | 0.012 |
|
| ||
| Days post transplantb (x) | 0.0004 (6.2 × 10−5) | 2.97 × 10−9 |
| (x') | −0.0012 (2.5 × 10−4) | 2.44 × 10−6 |
|
| ||
| Sex (Male vs. Female) | 0.034 (0.043) | 0.431 |
|
| ||
| Principal components (PCs) | ||
| PC1 | −0.85 (0.59) | 0.155 |
| PC2 | 0.28 (0.40) | 0.487 |
| PC3 | −0.34 (0.40) | 0.404 |
| PC4 | −0.25 (0.40) | 0.535 |
| PC5 | −0.20 (0.40) | 0.616 |
| PC6 | −0.74 (0.40) | 0.064 |
| PC7 | 0.09 (0.40) | 0.816 |
| PC8 | −0.27 (0.40) | 0.504 |
| PC9 | 0.57 (0.40) | 0.157 |
| PC10 | 0.48 (0.40) | 0.228 |
a
For coefficients with a positive value, the covariate results in an increase in log-transformed tacrolimus C/D ratio, whereas a negative values results in a decrease in log-transformed tacrolimus C/D ratio.
b
Restricted cubic spline functions with 3 knots were used to model nonlinear time trend and relationships, and x and x' are the corresponding linear and nonlinear terms.