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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Mol Cancer Ther. 2011 Sep 8;10(12):2287–2297. doi: 10.1158/1535-7163.MCT-11-0536

Figure 1.

Figure 1

a) Molecular structures of the thiazole antibiotic, thiostrepton, and DSPE-PEG2000-MeO, the PEGylated amphiphilic lipid used encapsulate thiostrepton into micellar nanoparticles. b) Representation of micelle-thiostrepton nanoparticles, depicting the solubilization of hydrophobic thiostrepton molecules in the inner hydrophobic compartment of the micelle nanoparticle. The nanoparticle is formed by the self assembly of DSPE-PEG2000-MeO and thiostrepton in aqueous solutions. c) Formulation studies to identify the lowest lipid-to-drug ratio required to completely encapsulate 1mM of thiostrepton. 3:1 lipid/drug ratio m/m was identified as the most acceptable ratio for further study. All measurements represent the average of 3 separate experiments, and error bars represent standard deviations.