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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Mol Cancer Ther. 2011 Sep 8;10(12):2287–2297. doi: 10.1158/1535-7163.MCT-11-0536

Figure 2.

Figure 2

a) Final nanoparticle-thiostrepton formulations (3:1 DSPE-PEG2000-MeO/thiostrepton, m/m) were found to be approximately 100nm in diameter and −16mV in zetapotential. b) Electron microscopy images of micelles only and micelle-thiostrepton confirm the dimensions of the micelle-encapsulated complexes. c) Release profile of thiostrepton from micellar vehicle (3:1 lipid/drug ratio, m/m) in serum solutions at 37°C that mimic in vivo environments (blood circulation). In high serum conditions, thiostrepton can remain encapsulated within micelle nanoparticles for at least 24 hours at 37°C. Each measurement represents the average of 3 separate experiments, and error bars represent standard deviations.