Table 1. Outcome measures collected at baseline and follow-up.
Measure: | Baseline: | Six-Month Follow-up: | 12-Month Follow-up: | 18-Month Follow-up: | 24-Month Follow-up: |
---|---|---|---|---|---|
UPDRS (Parts I-IV) (ON†) | 38 | 32 | 27 | 22 | 20 |
UPDRS-III (ON) | 13 | 14 | 8 | 6 | 9 |
UPDRS-III lateralized27 scores (ON) (R/L) | 6 / 4 | 3 / 7 | 2 / 5 | 2 / 4 | 3 / 6 |
UPDRS-III (OFF‡) | 20 | 23 | 19 | 25 | 24 |
UPDRS-III lateralized27 scores (OFF) (R/L) | 9 / 6 | 10 / 7 | 8 / 8 | 10 / 11 | 12 / 8 |
% time ON with dyskinesias | 0 | 0 | 0 | 0 | 0 |
Anti-PD medications (levodopa equivalents)28,29 | 225 | 133 | 133 | 436 | 361 |
IPG amplitude setting§ (R/L) | N/A | 1.5 / 1.5 | 1.8 / 1.8 | 1.8 / 1.8 | 1.8 / 1.8 |
PDQ-39 | 8.91 | UTD* | 2.34 |
ON refers to ON stimulation/ON medication (collected on day 1 of inpatient evaluation)
OFF refers to OFF stimulation/OFF medication (collected on day 8 of inpatient evaluation, after 7-day washout period)
§All other stimulation parameters remained constant throughout the two-year follow-up period: monopolar configuration with the case set to positive and the active contact set to negative (Left: contact 2; Right: contact 1) at a pulse width of 60 μs and frequency of 130 Hz.
Unable to do: one question was left unanswered by the subject. The scoring instructions for the PDQ-39 instrument state that if one item is left unanswered, the overall index cannot be calculated.