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Optimization of the Addition of Alkenyl-1,1-heterobimetallics to N-Pyridyl Sulfonyl Imines
 | ||||
|---|---|---|---|---|
| entry | R″2Zn | solvent | R | yield (%)a |
| 1 | Me2Zn | toluene | SO2Tol | trace |
| 2 | Me2Zn | toluene | Boc | trace |
| 3 | Me2Zn | toluene | P(O)Ph2 | <30 |
| 4 | Me2Zn | toluene | SO2(2-Py) | 73 |
| 5 | Me2Zn | THF | SO2(2-Py) | trace |
| 6 | Me2Zn | CH2Cl2 | SO2(2-Py) | 68b |
| 7 | Me2Zn | CH2Cl2 | SO2(2-Py) | 80 |
| 8 | Et2Zn | toluene | SO2(2-Py) | 64 |
| 9 | Et2Zn | CH2Cl2 | SO2(2-Py) | 65 |
Isolated yields,
Reaction performed at −10°C
