Table 2.
Univariate analysis of ABCB1, CYP3A4, CYP3A5, IL-10, and TNF genetic polymorphisms with SRL log (C/D) in renal transplant patients
| Gene | Nucleotide | Model | Coefficient | Standard Error | P Value | AIC Value |
|---|---|---|---|---|---|---|
| ABCB1 | 1236C>T | Co-dominant | 0.0770 | 0.0442 | 0.085 | −7.05 |
| 0.139 | 0.0578 | 0.0182 | ||||
| Dominant | 0.0955 | 0.0408 | 0.0193 | −7.89 | ||
| Recessive | 0.102 | 0.0544 | 0.0591 | −5.98 | ||
|
| ||||||
| ABCB1 | 2677G>T/A | Co-dominant | 0.0880 | 0.0458 | 0.0582 | −9.16 |
| 0.145 | 0.0516 | 0.0063 | ||||
| Dominant | 0.111 | 0.0400 | 0.0056 | −10.1 | ||
| Recessive | 0.110 | 0.0490 | 0.0251 | −7.43 | ||
|
| ||||||
| ABCB1 | 3435C>T | Co-dominant | 0.183* | 0.0421 | <0.0001 | −18.6 |
| 0.135** | 0.0510 | 0.01 | ||||
| Dominant | 0.167 | 0.0387 | <0.0001 | −19.7 | ||
| Recessive | 0.0445 | 0.0512 | 0.381 | −3.19 | ||
|
| ||||||
| CYP3A4 | −392A>G | Co-dominant | −0.0211 | 0.0534 | 0.693 | −0.744 |
| −0.0348 | 0.0767 | 0.651 | ||||
| Dominant | −0.0252 | 0.0465 | 0.584 | −2.72 | ||
| Recessive | −0.0306 | 0.0760 | 0.684 | −2.58 | ||
|
| ||||||
| CYP3A5 | 6986A>G | Co-dominant | −0.0848 | 0.0552 | 0.128 | −2.88 |
| −0.0378 | 0.0682 | 0.581 | ||||
| Dominant | −0.0672 | 0.0464 | 0.146 | −4.53 | ||
| Recessive | −0.200 | 0.0682 | 0.767 | −2.51 | ||
|
| ||||||
| CYP3A5 | 14690G>A | Dominant | 0.208 | 0.108 | 0.0551 | −6.10 |
|
| ||||||
| IL-10 | −1082G>A | Co-dominant | 0.0488 | 0.0456 | 0.288 | −6.76 |
| 0.140 | 0.0553 | 0.0130 | ||||
| Dominant | 0.0773 | 0.0435 | 0.0763 | −5.56 | ||
| Recessive | 0.111 | 0.0484 | 0.0228 | −7.60 | ||
|
| ||||||
| TNF | −308G>A | Co-dominant | 0.0513 | 0.0451 | 0.259 | −2.30 |
| 0.179 | 0.218 | 0.415 | ||||
| Dominant | 0.0550 | 0.0446 | 0.215 | −3.96 | ||
| Recessive | 0.163 | 0.219 | 0.452 | −2.99 | ||
ABCB1 3435CT;
ABCB1 3435TT