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. Author manuscript; available in PMC: 2012 Dec 27.
Published in final edited form as: Transplantation. 2011 Dec 27;92(12):1342–1347. doi: 10.1097/TP.0b013e3182384ae2

Table 2.

Univariate analysis of ABCB1, CYP3A4, CYP3A5, IL-10, and TNF genetic polymorphisms with SRL log (C/D) in renal transplant patients

Gene Nucleotide Model Coefficient Standard Error P Value AIC Value
ABCB1 1236C>T Co-dominant 0.0770 0.0442 0.085 −7.05
0.139 0.0578 0.0182
Dominant 0.0955 0.0408 0.0193 −7.89
Recessive 0.102 0.0544 0.0591 −5.98

ABCB1 2677G>T/A Co-dominant 0.0880 0.0458 0.0582 −9.16
0.145 0.0516 0.0063
Dominant 0.111 0.0400 0.0056 −10.1
Recessive 0.110 0.0490 0.0251 −7.43

ABCB1 3435C>T Co-dominant 0.183* 0.0421 <0.0001 −18.6
0.135** 0.0510 0.01
Dominant 0.167 0.0387 <0.0001 −19.7
Recessive 0.0445 0.0512 0.381 −3.19

CYP3A4 −392A>G Co-dominant −0.0211 0.0534 0.693 −0.744
−0.0348 0.0767 0.651
Dominant −0.0252 0.0465 0.584 −2.72
Recessive −0.0306 0.0760 0.684 −2.58

CYP3A5 6986A>G Co-dominant −0.0848 0.0552 0.128 −2.88
−0.0378 0.0682 0.581
Dominant −0.0672 0.0464 0.146 −4.53
Recessive −0.200 0.0682 0.767 −2.51

CYP3A5 14690G>A Dominant 0.208 0.108 0.0551 −6.10

IL-10 −1082G>A Co-dominant 0.0488 0.0456 0.288 −6.76
0.140 0.0553 0.0130
Dominant 0.0773 0.0435 0.0763 −5.56
Recessive 0.111 0.0484 0.0228 −7.60

TNF −308G>A Co-dominant 0.0513 0.0451 0.259 −2.30
0.179 0.218 0.415
Dominant 0.0550 0.0446 0.215 −3.96
Recessive 0.163 0.219 0.452 −2.99
*

ABCB1 3435CT;

**

ABCB1 3435TT