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CORT is increased in FR animals and is necessary for gene up-regulation in the food restricted state. Blood plasma CORT levels were found to be significantly increased in 1-, 5-, and 10-day FR animals (A). Cdkn1a was significantly up-regulated in the Acb of an independent cohort of 5-day FR animals, however was not up-regulated in the Acb of 5-day FR adrenalectomized mice (B). Similar results were found with Arrdc2 (C) and Angptl4 (D). #=P=0.051, *= P < 0.05, n=5 mice per group.
