Figure 1. Survival curves of Trp53^KO, Trp53^KO;Tgfbr2^KO, Tgfbr2^KO and Control mice.

52% of Trp53^KO mice (N=29) died by 50 weeks whereas 3% of Trp53^KO;Tgfbr2^KO mice (N=36) died by 50 weeks and no Tgfbr2^KO mice (N=19) died by 50 weeks. Seven percent of Control mice (N=14) died by 50 weeks of age. A significant decrease in the survival of Trp53^KO mice as compared to Trp53^KO;Tgfbr2^KO, Tgfbr2^KO or Control mice was observed (P = 0.0001, 0.0213, 0.0082, respectively). There was no significant difference in survival between the Trp53^KO;Tgfbr2^KO, Tgfbr2^KO or Control mice (P = 0.4590, Log rank Test).