Skip to main content
. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Semin Immunopathol. 2011 Jul 31;34(1):73–91. doi: 10.1007/s00281-011-0287-3

Fig. 2.

Fig. 2

Regulation of lymphocyte trafficking by S1P. Lymphocytes in circulation have their S1P1 mostly internalized due to the high S1P concentration in plasma. Upon entrance in secondary lymphoid organs where S1P concentration is low, they gradually recover the surface expression of S1P1 and regain ability to egress from the lymphoid organs toward S1P in circulation. FTY720 is phosphorylated by sphingosine kinase 2 and induces the internalization and degradation of S1P1 and thereby inhibits the lymphocyte egress