Table 2.

Psychological dysregulation and white matter variables for adolescents with substance use disorders (SUD) and control adolescents.

	SUD (n=35)			Control (n=20)			Main effects
	mean	s.d.	range	mean	s.d.	range	F	p
Psychological Dysregulation
BRIEF	61.4	14.4	34–91	42.6	9.8	30–69	218.1	.001
Psychopatholgy Symptoms	7.8	6.6	0–22	1.6	4.5	0–20	310.2	<.001
White Matter Volumes
Prefrontal	5.6	.4	5.0–6.3	5.9	.5	4.8–7.0	2.8	.3
Orbitofrontal	1.4	.1	1.2–1.6	1.4	.1	1.2–1.7	.7	.7
Cingulate	1.6	.1	1.4–1.8	1.6	.1	1.4–1.8	.6	.6
Parietal	3.1	.2	2.6–3.5	3.0	.2	2.7–3.4	3.7	.3
Temporal	2.6	.2	2.4–2.9	2.7	.2	2.3–3.4	0.8	.5
White Matter FA
Prefrontal	.348	.021	.29–.39	.353	.013	.33–.39	23.4	.005
Parietal	.364	.035	.28–.42	.378	.028	.32–.43	21.6	.03
Orbitofrontal	.326	.026	.27–.39	.323	.018	.29–.36	0.1	.7
Cingulate	.484	.033	.41–.55	.483	.028	.43–.56	1.1	.5
Temporal	.312	.023	.26–.36	.319	.015	.29–.35	13.1	.03

Footnote: Abbreviations: DBD: disruptive behavior disorders; FA: fractional anisotropy