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. Author manuscript; available in PMC: 2012 Dec 15.
Published in final edited form as: J Immunol. 2011 Nov 9;187(12):6197–6207. doi: 10.4049/jimmunol.1101348

Figure 7. Deletion of CARMA1 by OX40-Cre impairs the function of memory T cells.

Figure 7

A) Experimental protocol used for in vitro Th2 polarization and adoptive transfer of CD4+ T cells from OX40+/CreCARMA1F/F, OX40+/+CARMA1F/F, and OX40+/CreCARMA1+/+ mice. B) Intracellular IL-4 production following PMA and Ionomycin restimulation of Th2 polarized CD4+ T cells on day 6. C, D and E) Total cell number, percentage and number of individual cell types in the BAL fluid recovered from Thy1.1+ recipient mice. F and G) Percentage and (H and I) number of Thy1.2+ (donor) activated, effector and memory CD4+ T cell subsets recovered in the BAL fluid from recipient Thy1.1+ mice. Data for C to I reported as mean ± SEM from 5–10 recipient mice per donor genotype from 2 separate experiments. *p<0.05 by one-way ANOVA.